Responsibilities: The Rau lab is a translational leukemia lab with expertise in the biology of hematologic malignancies. The focus of the lab is the genomic and epigenetics of leukemogenesis and chemoresistance. The lab's recent work includes a translational study defining the histone modifier, DOT1L as a novel epigenetic target for the treatment of acute myeloid leukemia (AML) with mutations of the gene DNMT3A, defining the SWI/SNF complex as a targetable vulnerability in pediatric AML, use of CRISPR/Cas9 to model genetic lesions leading to chemotherapy resistance in human leukemia and multiple projects examining the interaction of co-occurring mutations in murine models of leukemia. For this work we use a variety of lab techniques including mouse modeling, genome engineering, in vitro and in vivo drug testing and next generation sequencing to study the genetic, transcriptomic and epigenetic underpinnings of hematology malignancies. This is a unique type of position that requires significant individual initiative and motivation to learn and understand both existing and new scientific methods and knowledge. The Research Scientist will be given the opportunity and be responsible for conducting independent and creative research related to the overall mission of the laboratory. This is an ideal position for those considering graduate school in a related field or medical school in the near future (up to two years). Overall responsibilities include acquiring an in-depth understanding of the field in which they are working, and working with the PI, as well as independently, on the planning, design, execution, trouble-shooting, and interpretation of experiments; makes detailed observations, records data and presents results; assists post docs and fellows in the day-to-day activities and interprets experiments related to assigned projects. The Research Scientist will spend the majority of their time making contributions to on-going laboratory projects, requiring the ability to use independent judgment to address tasks and projects, and will identify and refine existing procedures and practices. The incumbent may also participate in the management of a small rodent colony. Requirements: Required Education/Experience: Bachelor's Degree in biology, microbiology, immunology, molecular biology or biochemistry. Prior experience in a laboratory setting. Required Credentials: N/A. Preferred: Research experience in biochemistry, molecular biology, and tissue culture techniques is highly preferred. Min to Max Hourly Salary: $25.09 - $37.64 /hr Min to Max Annual Salary: $52,187.20 - $78,291.20 /yr Salary Information: This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided. The union pay ranges can be found on the Seattle Children's website here: - Seattle Children's offers annual incentive pay based upon performance that is commensurate with the level of the position. Disclaimer for Out of State Applicants: This compensation range is specific to Seattle, positions located outside of Seattle may be compensated differently depending on various factors. Benefits Information: Seattle Children's offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. for more information. About Us: Hope. Care. Cure. These three simple words capture what we do at Seattle Children's - to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE As one of the nation's top five pediatric research centers, Seattle Children's Researc